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I've experienced plenty of problems with Pulseaudio and Skype output sound hell crappy. This stupid proprietary program Skype is a total crap … Anyways again thanks to ArchLinux's wiki, I've used the two mentioned steps to fix all this Skype in / out problems …
1. Fix problems with Glitches, voice skips and crackling In file /etc/pulse/default.pa its necessery to substitute the line;
load-module module-udev-detect tsched=0
2. Resolve Choppy sound in (Pulseaudio) -> Skype
In /etc/pulse/daemon.conf two lines has to be also substituted:
; default-sample-rate = 44100
default-sample-rate = 48000
3. Change /etc/default/pulseaudio to allow dynamic module loading
It is a good idea to the default settings from DISALLOW_MODULE_LOADING=1 to DISALLOW_MODULE_LOADING=0 .This step is not required and I'm not sure if it has some influence on solving sound in / out problems with Skype but I believe it can be helpful in some cases..
So in /etc/default/pulseaudio Substitute:
4. Restart PulseAudio server
After the line is changed and substituted a restart of PulseAudio is required. For PulseAudio server restart a gnome session logout is necessery. Just LogOff logged Gnome user and issue cmd:
debian:~# pkill pulseaudio
This will kill any left pulseaudio server previous instances.