For generations we have been encouraged to eat an apple-a-day in order to stay healthy and keep the doctor at bay. Today, the new apple may just be the grapefruit. Let’s look at the benefits of grapefruit: Appetite Loss: Grapefruit reduces the feeling of hunger. This is the reason why people include grapefruit in their weight loss programs. High fiber contained by this fruit can satisfy hunger and thus may avoid any overeating temptation. Grapefruit juice, if combined with water, can quench the thirst. Fatigue: Grapefruit is beneficial in the treatment of fatigue. It helps to dispel fatigue and general tiredness. It can bring about a refreshing feeling in you when you drink equal amount of grapefruit juice and lemon juice. Acidity: The fresh grapefruit juice has alkaline reaction after digestion. The citric acid increases the effect of the alkalinity reaction after digestion. The juice extracted from the grapefruit is beneficial in preventing the acid formation and many other diseases that arise due to the presence of acidity in the body. Indigestion: Grapefruit is useful for solving the problem of indigestion. It is very light as compared to other food articles and thus, acts immediately on indigestion by easing the heat and irritation caused in the stomach. It improves the flow of digestive juices, thereby improving the digestive systems. Insomnia: A simple glass of grapefruit juice, if drunk before going to bed, can promote healthy and sweet sleep and thus, alleviates insomnia. Constipation: A glass full of fresh squeezed grapefruit in the morning is the best remedy to control the constipation. Grapefruits are high in fiber and they result best in stimulating the colon and other parts of the body. Urinary Disorders: Grapefruit juice is quite rich in potassium and vitamin C and thus, works as the best medicine in the case of recurrent urinary tract infections. Lowers Cholesterol: The Journal of Agricultural and Food Chemistry shows that consumption of grapefruit can reduce LDL (“bad”) cholesterol, as well as triglycerides. Caveats on grapefruit As with any medication, there are considerations about the use of grapefruit with medications. More than 50 prescription and over-the-counter drugs are affected by grapefruit juice, including some of the most commonly prescribed medications. This list includes a number of medications used to treat high cholesterol, high blood pressure, depression, pain, erectile dysfunction, and allergies. Grapefruit contains a substance that inhibits the enzyme called CYP3A4. This powerful enzyme breaks down numerous medications such as the cholesterol-lowering drug, Lipitor. Patients who take Lipitor, or some antidepressant medication, and eat grapefruit, can have toxic levels of the medications because the grapefruit inhibits CYP34A. So what are patients to do? Check with your healthcare provider or pharmacist to find out about your specific drug. All new medications are tested for drug interactions, including grapefruit juice, before they are approved by the U.S. Food and Drug Administration (FDA). When you order medications in the mail or pick them up at your local pharmacy, you should receive a patient information sheet, which will let you know if your drug is affected by grapefruit juice. Some pharmacies may also put a warning label on your medication bottle. If you are not sure, ask the pharmacist. Bottom Line: Grapefruit juice may be helpful for many conditions and improve overall health. However, there are precautions about using grapefruit because of interactions with certain medications. If you have any questions, check with your doctor or your pharmacist. Written by Doctor Neil Baum