If you're running a small home based Linux or BSD server with Qmail, Exim or Postfix and it happens your ISP has filtered incoming connections to TCP/IP port 25 and you wonder if it is possible to use other alternative port to 25 for example the (Secure SMTP) SMTPS 465 supported by all major SMTP servers, the answer unfortunately is it is not possible.
The only accepted and working mail transmission port works on TCP/IP Port 25, thus the only option to make the mail server working fine is contact your ISP and convince them to remove filtering for port 25 to your custom IP. Many ISPs set a Firewall filter for 25, because nowadays many Windows XP / Vista / 7 PCs get infected with Viruses and Trojans running a tiny SMTP server on the host and trying to send million of SPAM messages via the poor unknowing victim. This congests the network and often even creates ISP network overloads, thus ISPs prefer to filter Port 25 to get rid of such eventual problems.
Once again, alternative port to 25 for Mail is impossible !